Mismodeled purines: implicit alternates and hidden Hoogsteens
نویسندگان
چکیده
منابع مشابه
Discovering Hidden Contextual Factors for Implicit Feedback
This paper presents a statistical framework based on Principal Component Analysis (PCA) for discovering the contextual factors which most strongly influence user behavior during information-seeking activities. We focus particular attention on explaining how PCA can be used to assist in the discovery of contextual factors. As a demonstration of the utility of PCA, we employ it in an Implicit Rel...
متن کاملPurines and sensory nerves.
P2X and P2Y nucleotide receptors are described on sensory neurons and their peripheral and central terminals in dorsal root, nodose, trigeminal, petrosal, retinal and enteric ganglia. Peripheral terminals are activated by ATP released from local cells by mechanical deformation, hypoxia or various local agents in the carotid body, lung, gut, bladder, inner ear, eye, nasal organ, taste buds, skin...
متن کاملNucleotide Metabolism – Purines and Pyrimidines
Nucleotide metabolism results in the synthesis of the four nucleotides that form DNA. These are further divided in two categories: purines and pyrimidines. Their construction and degradation takes place in a progression of single steps, while different enzymes and cofactors are involved in the process. Beside degradation, there is also a form of reprocessing purine and pyrimidine nucleotides, d...
متن کاملPurines, Purinergic Receptors, and Cancer
Purines were long thought to be restricted to the intracellular compartment, where they are used for energy transactions, nucleic acid synthesis, and amultiplicity of biochemical reactions. However, it is now clear that both adenosine and adenosine triphosphate are (i) abundant biochemical components of the tumor microenvironment, (ii) potent modulators of immune cell responses and cytokine rel...
متن کاملPurines, purinergic receptors, and cancer.
Purines were long thought to be restricted to the intracellular compartment, where they are used for energy transactions, nucleic acid synthesis, and a multiplicity of biochemical reactions. However, it is now clear that both adenosine and adenosine triphosphate are (i) abundant biochemical components of the tumor microenvironment, (ii) potent modulators of immune cell responses and cytokine re...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Acta Crystallographica Section D Structural Biology
سال: 2017
ISSN: 2059-7983
DOI: 10.1107/s2059798317013729